Iatrogenic bile duct injuries: diagnostic and therapeutic update from a safe surgical approach
Keywords:
Iatrogenic injuries; bile duct; cholecystectomy; laparoscopic surgery; hepaticojejunostomy; surgical preventionAbstract
Introduction:
Iatrogenic bile duct injuries (IBDI) represent one of the most feared complications of cholecystectomy, particularly when performed laparoscopically. Their clinical impact includes high morbidity, risk of sepsis, late strictures, and deterioration of quality of life.
Objective:
To update the diagnostic, therapeutic, and preventive aspects of IBDI, highlighting surgical principles that favor a safe and effective resolution.
Method:
A narrative literature review was conducted using the PubMed, SciELO, LILACS, and Google Scholar databases, prioritizing original articles, systematic reviews, and clinical guidelines published between 2020 and 2024. A total of 30 relevant references were selected based on recency, open access availability, and thematic relevance.
Development:
This section describes risk factors, the Strasberg classification, clinical manifestations, diagnostic methods (including intraoperative cholangiography and MR cholangiopancreatography), and therapeutic strategies according to the type of injury. Endoscopic, percutaneous, and surgical options are addressed, with emphasis on hepaticojejunostomy for complex injuries. Preventive principles such as the critical view of safety and subtotal cholecystectomy in difficult scenarios are also reviewed.
Conclusions:
Successful management of IBDI depends on early diagnosis, accurate classification, and individualized treatment by experienced teams. Prevention through standardized surgical techniques remains the most effective strategy to reduce their incidence.
Keywords:
Iatrogenic injuries; bile duct; cholecystectomy; laparoscopic surgery; hepaticojejunostomy; surgical prevention.
Downloads
References
1. Connor S, Garden OJ. Bile duct injury in the era of laparoscopic cholecystectomy. Br J Surg[internet]. 2006[citado 18/08/2026]; 93(2): 158-68. Disponible en: https://doi.org/10.1002/bjs.5266
2. de'Angelis N, Catena F, Memeo R, Coccolini F, Martínez-Pérez A, Romeo OM, et al. 2020 WSES guidelines for the detection and management of bile duct injury during cholecystectomy. World J Emerg Surg[internet]. 2021[citado 18/08/2026]; 16(1): 30. Disponible en: https://doi.org/10.1186/s13017-021-00369-w
3. Booij KAC, de Reuver PR, van Dieren S, van Delden OM, Rauws EA, Busch OR, et al. Long-term Impact of Bile Duct Injury on Morbidity, Mortality, Quality of Life, and Work Related Limitations. Ann Surg[internet]. 2018[citado 18/08/2026]; 268(1): 143-150. Disponible en: https://doi.org/10.1097/SLA.0000000000002258
4. Strasberg SM, Hertl M, Soper NJ. An analysis of the problem of biliary injury during laparoscopic cholecystectomy. J Am Coll Surg[internet]. 1995[citado 18/08/2026]; 180(1): 101-25. Disponible en: https://pubmed.ncbi.nlm.nih.gov/8000648/
5. Nuzzo G, Giuliante F, Giovannini I, Ardito F, D'Acapito F, Vellone M, et al. Bile duct injury during laparoscopic cholecystectomy: results of an Italian national survey on 56 591 cholecystectomies. Arch Surg[internet]. 2005[citado 18/08/2026]; 140(10): 986-92. Disponible en: https://doi.org/10.1001/archsurg.140.10.986
6. Gigot J, Etienne J, Aerts R, Wibin E, Dallemagne B, Deweer F, et al. The dramatic reality of biliary tract injury during laparoscopic cholecystectomy. An anonymous multicenter Belgian survey of 65 patients. Surg Endosc[internet]. 1997[citado 18/08/2026]; 11(12): 1171-8. Disponible en: https://doi.org/10.1007/s004649900563
7. Viste A, Horn A, Øvrebø K, Christensen B, Angelsen JH, Hoem D. Bile duct injuries following laparoscopic cholecystectomy. Scand J Surg[internet]. 2015[citado 18/08/2026]; 104(4): 233-7. Disponible en: https://doi.org/10.1177/1457496915570088
8. Halbert C, Pagkratis S, Yang J, Meng Z, Altieri MS, Parikh P, et al. Beyond the learning curve: incidence of bile duct injuries following laparoscopic cholecystectomy normalize to open in the modern era. Surg Endosc[internet]. 2016[citado 18/08/2026]; 30(6): 2239-43. Disponible en: https://doi.org/10.1007/s00464-015-4485-2
9. Way LW, Stewart L, Gantert W, Liu K, Lee CM, Whang K, et al. Causes and prevention of laparoscopic bile duct injuries: analysis of 252 cases from a human factors and cognitive psychology perspective. Ann Surg[internet]. 2003[citado 18/08/2026]; 237(4): 460-9. Disponible en: https://doi.org/10.1097/01.sla.0000060680.92690.e9
10. Moore DE, Feurer ID, Holzman MD, Wudel LJ, Strickland C, Gorden DL, et al. Long-term detrimental effect of bile duct injury on health-related quality of life. Arch Surg[internet]. 2004[citado 18/08/2026]; 139(5): 476-81. Disponible en: https://doi.org/10.1001/archsurg.139.5.476
11. Burns R, Connor KL, Guest RV, Johnston CC, Harrison EM, Wigmore SJ, et al. Risk factors and mitigating measures associated with bile duct injury during cholecystectomy: meta-analysis. BJS Open[internet]. 2025[citado 18/08/2026]; 9(4). Disponible en: https://doi.org/10.1093/bjsopen/zraf076
12. Fingerhut A, Dziri C, Garden OJ, Gouma D, Millat B, Neugebauer E, et al. ATOM, the all-inclusive, nominal EAES classification of bile duct injuries during cholecystectomy. Surg Endosc[internet]. 2013[citado 18/08/2026]; 27(12): 4608-19. Disponible en: https://doi.org/10.1007/s00464-013-3081-6
13. Stewart L, Way LW. Bile duct injuries during laparoscopic cholecystectomy. Factors that influence the results of treatment. Arch Surg[internet]. 1995[citado 18/08/2026]; 130(10): 1123-8. Disponible en: https://doi.org/10.1001/archsurg.1995.01430100101019
14. Brunt LM, Deziel DJ, Telem DA, Strasberg SM, Aggarwal R, Asbun H, et al. Safe Cholecystectomy Multi-society Practice Guideline and State of the Art Consensus Conference on Prevention of Bile Duct Injury During Cholecystectomy. Ann Surg[internet]. 2020[citado 18/08/2026]; 272(1): 3-23. Disponible en: https://doi.org/10.1097/sla.0000000000003791
15. Marichez A, Adam JP, Laurent C, Chiche L. Hepaticojejunostomy for bile duct injury: state of the art. Langenbecks Arch Surg[internet]. 2023[citado 18/08/2026]; 408(1): 107. Disponible en: https://doi.org/10.1007/s00423-023-02818-3
16. de Reuver PR, Grossmann I, Busch OR, Obertop H, van Gulik TM, Gouma DJ. Referral pattern and timing of repair are risk factors for complications after reconstructive surgery for bile duct injury. Ann Surg[internet]. 2007[citado 18/08/2026]; 245(5): 763-70. Disponible en: https://doi.org/10.1097/01.sla.0000252442.91839.44
17. Perera MT, Silva MA, Hegab B, Muralidharan V, Bramhall SR, Mayer AD, et al. Specialist early and immediate repair of post-laparoscopic cholecystectomy bile duct injuries is associated with an improved long-term outcome. Ann Surg[internet]. 2011[citado 18/08/2026]; 253(3): 553-60. Disponible en: https://doi.org/10.1097/sla.0b013e318208fad3
18. Halle-Smith JM, Hall LA, Mirza DF, Roberts KJ. Risk factors for anastomotic stricture after hepaticojejunostomy for bile duct injury-A systematic review and meta-analysis. Surgery[internet]. 2021[citado 18/08/2026];170(5): 1310-1316. Disponible en: https://doi.org/10.1016/j.surg.2021.05.015
19. Sicklick JK, Camp MS, Lillemoe KD, Melton GB, Yeo CJ, Campbell KA, et al. Surgical management of bile duct injuries sustained during laparoscopic cholecystectomy: perioperative results in 200 patients. Ann Surg[internet]. 2005[citado 18/08/2026]; 241(5): 786-92. Disponible en: https://doi.org/10.1097/01.sla.0000161029.27410.71
20. Spiers HVM, Lam S, Machairas NA, Sotiropoulos GC, Praseedom RK, Balakrishnan A. Liver transplantation for iatrogenic bile duct injury: a systematic review. HPB (Oxford) [internet]. 2023[citado 18/08/2026]; 25(12): 1475-1481. Disponible en: https://doi.org/10.1016/j.hpb.2023.08.004
21. Manatakis DK, Antonopoulou MI, Tasis N, Agalianos C, Tsouknidas I, Korkolis DP, et al. Critical View of Safety in Laparoscopic Cholecystectomy: A Systematic Review of Current Evidence and Future Perspectives. World J Surg[internet]. 2023[citado 18/08/2026]; 47(3): 640-648. Disponible en: https://doi.org/10.1007/s00268-022-06842-0
22. Georgiou K, Sandblom G, Alexakis N, Enochsson L. Intraoperative cholangiography 2020: Quo vadis? A systematic review of the literature. Hepatobiliary Pancreat Dis Int[internet]. 2022[citado 18/08/2026]; 21(2): 145-153. Disponible en: https://doi.org/10.1016/j.hbpd.2022.01.002
23. Nzenwa IC, Mesri M, Lunevicius R. Risks associated with subtotal cholecystectomy and the factors influencing them: A systematic review and meta-analysis of 85 studies published between 1985 and 2020. Surgery[internet]. 2021[citado 18/08/2026]; 170(4): 1014-1023. Disponible en: https://doi.org/10.1016/j.surg.2021.03.036
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2026 Roberto Lázaro Blanco Sosa, Jose Antonio Copo de Armas, Lenyn Daniel Montes Sevilla

This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who have published with this journal accept the following terms: authors will retain their copyright and guarantee the journal the right of first publication of their work, which will be simultaneously subject to the Creative Commons recognition license that allows third parties to share the work as long as its author is indicated and its first publication is this journal. Authors may adopt other non-exclusive license agreements for the distribution of the version of the published article (e.g., deposit it in an institutional telematic archive or publish it in a monographic volume) provided that the initial publication in this journal is indicated. Authors are permitted and encouraged to disseminate their article using Internet (e.g., in institutional telematic archives or on their website) before and during the submission process, which may lead to interesting exchanges and increased citations of the published work. (See The Effect of Open Access).

