Cardiovascular system involvement in SARS-CoV-2 infection

Authors

  • Jairo Jesus Gómez-Tejeda Universidad de Ciencias Mèdicas de Holguin. Cuba
  • Claudia Hernandez-Perez Universidad de Ciencias Medicas de Holguin. Cuba
  • Yoandri Aguilera-Velazquez Universidad de Ciencias Medicas de Holguin. Cuba

Keywords:

coronavirus, COVID-19, SARS-CoV-2, hypertension, arrhythmias, cardiomyopathies

Abstract

Introduction: COVID-19 is an emerging disease with global incidence, which exhibits a greater number of complications in patients with comorbidities, mainly in those with a history of cardiovascular disease.

Objective: to describe the implications of COVID-19 in the cardiovascular system.

Method: A review of the literature was conducted in the MEDLINE, SciELO, JAMA and Elsevier databases, recovering 35 articles, which were taken as the basis for the present review. The combination of terms using search formulas was used to retrieve articles.

Development: COVID-19 can be variable in correspondence with the presentation form and accompanying symptoms, as well as the recipient's immune response. SARS-CoV-2 binds to cells through the viral spike structural protein that binds to the angiotensin-converting enzyme 2 receptor from viral receptors; therefore, hypertensive patients or those with other cardiovascular conditions have a higher risk of developing severe forms of COVID-19. Among the cardiovascular diseases associated with infection by a coronavirus, myocarditis, arrhythmias, acute myocardial infarction and heart failure stand out.

Conclusions: the main cardiovascular implications in patients with COVID-19 are arrhythmia, thromboembolic disease, myocarditis, heart failure of acute onset and myocardial infarction, which condition a more serious picture of the disease. The inflammatory response, hemodynamic changes secondary to the viral process, as well as hypoxemia, constitute mechanisms of negative impact on cardiovascular health, leading to the development of acute cardiac injury.

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References

1. Pérez Abreu MR, Gómez Tejeda JJ, Dieguez Guach RA. Características clínico-epidemiológicas de la COVID-19. Rev haban cienc méd [Internet]. 2020 [citado 25/4/2020]; 19(2):e3254. Disponible en: http://www.revhabanera.sld.cu/index.php/rhab/article/view/3254/2505

2. Serra Valdés MA. Infección respiratoria aguda por COVID-19: una amenaza evidente. Rev haban cienc méd [Internet]. 2020 [citado 24/03/2020]; 19(1):1-5. Disponible en: http://www.revhabanera.sld.cu/index.php/rhab/article/view/3171

3. Cuba frente a la COVID-19, día 47: Últimas noticias [Internet]. Cubadebate [actualizado 26/04/2020, citado 27/04/2020]. Disponible en: http://www.cubadebate.cu/noticias/2020/04/26/cuba-frente-a-la-COVID-19-dia-47-ultimas-noticias/

4. World Health Organization. Clinical management of severe acute respiratory infection when novel coronavirus (nCoV) infection is suspected. [Internet]. 2020 [citado 24/4/2020]. Disponible en: https://www.who.int/publications-detail/clinical-management-of-severe-acute-respiratory-infection-when-novel-coronavirus-(ncov)-infection-is-suspected

5. Parte de cierre del día 13 de mayo de 2020 a las 12 de la noche [Internet]. MINSAP. 2020 [Actualizado 13/05/2020, Citado 14/05/2020]. Disponible en: https://www.salud.msp.gob.cu/?p=5248

6. Actualización epidemiológica. Nuevo coronavirus (2019-nCoV) [Internet]. INFOMED [actualizado 28/01/2020, citado 25/04/2020]. Disponible en: https://temas.sld.cu/coronavirus/2020/01/28/nuevo-coronavirus-2019-ncov-actualizacion

7. Naranjo-Dominguez A, Valdés Martín A. COVID- 19. Punto de vista del cardiólogo. Rev Cuban Cardiol [Internet]. 2020[citado 25/4/220]; 26(1). Disponible desde: http://www.revcardiologia.sld.cu/index.php/revcardiologia/article/view/951

8. Giralt-Herrera A, Rojas-Velázquez JM, Leiva-Enríquez J. Relación entre COVID-19 e Hipertensión Arterial. Rev haban cienc méd [Internet]. 2020 [citado 25/4/220]; 19(2):e_3246. Disponible en: http://www.revhabanera.sld.cu/index.php/rhab/article/view/324 6

9. Sellén Crombet J, Sellén Sánchén E, Sellén Fundora L, Pena Pérez EE. Relación entre sistema renina angiotensina e infección por COVID−19. Rev haban cienc méd [Internet]. 2020[citado 25/4/220]; 19(2):e_3302. Disponible en: http://www.revhabanera.sld.cu/index.php/rhab/article/view/3302/2500.

10. Alexandre J, Cracowski J, Richard V, Bouhanick B. Renin-angiotensin-aldosterone system and COVID-19 infection. Annales d’Endocrinologie [Internet]. 2020 [citado 25/4/220]; [article in press]. Disponible en: https://doi.org/10.1016/j.ando.2020.04.005

11. Rothan HA, Byrareddy SN. The epidemiology and pathogenesis of coronavirus disease (COVID-19) outbreak. Journal of Autoimmunity [Internet]. 2020 [citado 25/04/2020]; [article in press]. Disponible en: https://doi.org/10.1016/j.jaut.2020.102433

12. García Hernández RA, Rivero Seriel L, Aroche Aportela R, Aldama Pérez LI, Hernández Navas M. COVID-19: en torno al sistema cardiovascular. Anales de la Academia de Ciencias de Cuba [Internet]. 2020 [citado 26/04/2020]; 10(2):especial COVID-19. Disponible en: http://www.revistaccuba.sld.cu/index.php/revacc/article/view/782

13. Moreno Martínez FL, Moreno López FL, Oroz Moreno R. Repercusión cardiovascular de la infección por el nuevo coronavirus SARS-CoV-2(COVID-19). CorSalud [Internet]. 2020 [citado 14/05/2020]; 12(1):3-17. Disponible en: http://www.revcorsalud.sld.cu/index.php/cors/article/view/588

14. Gauna ME, Bernava JL. Recomendaciones diagnostica y terapéuticas ante la Respuesta Inmune Trombotica Asociada a COVID-19 (RITAC). CorSalud [Internet]. 2020 [14/05/2020]; 12(1): 60-63. Disponible en: http://www.revcorsalud.sld.cu/index.php/cors/article/view/615

15. Cepero-Llauger K, Pardo-Ramírez I, Gómez León M. Respuesta inmunitaria y trombótica en pacientes con síndrome de dificultad respiratoria aguda en la neumonía por SARS-CoV-2. Anales de la Academia de Ciencias de Cuba [Internet]. 2020[citado 14/05/2020]; 10(2):[aprox. 0 p.]. Disponible en: http://www.revistaccuba.sld.cu/index.php/revacc/article/view/782

16. Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. The Lancet [Internet]. 2020 [citado 26/4/2020]; 395(10223): 497-506. Disponible en: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)30183-5/fulltext

17. Calvo C. Recomendaciones sobre el manejo clínico de la infección por el nuevo coronavirus SARS-CoV2. An Pediatr (Barc) [Internet]. 2020[citado 23/4/2020]; 30(20):11. Disponible en: https://doi.org/10.1016/j.anpedi.2020.02.001

18. Triana JFF, Márquez DAS, Silva JSC, Castro CCA, Sandoval AFB, COVID-19 y enfermedad cardiovascular. Revista Colombiana de Cardiología [Internet]. 2020[citado 25/4/2020]; [article in press]. Disponible en: https://doi.org/10.1016/j.rccar.2020.04.004

19. Shi S, Qin M, Shen B. Cardiac injury in patients with coronavirus disease 2019. JAMA Cardiol [Internet]. 2020 [citado 24/4/2020]; [article in press]. Disponible en: https://doi.org/10.1001/jamacardio.2020.0950

20. Long B, Brady WJ, Koyfman A. Cardiovascular complications in COVID-19. American Journal of Emergency Medicine [Internet]. 2020 [citado 25/4/220]; [article in press]. Disponible en: https://doi.org/10.1016/j.ajem.2020.04.048

21. Fang L, Karakiulakis G, Roth M. Are patients with hypertension and diabetes mellitus at increased risk for COVID-19 infection? Lancet Respir Med [Internet]. 2020. [citado 23/03/2020]; [article in press]. Disponible en: https://doi.org/10.1016/S2213-2600(20)30116-8

22. Chang,Y, Wang L. Coronavirus Disease 2019: Coronaviruses and Blood Safey. Transfusion Medicine Reviews [Internet]. 2020 [citado 24/04/2020]; [article in press]. Disponible: https://doi.org/10.1016/j.tmrv.2020.02.003

23. Li G, Hu R, Gu X. A close-up on COVID-19 and cardiovascular diseases. Nutrition, Metabolism and Cardiovascular Diseases [Internet]. 2020 [citado 24/04/2020]; [article in press]. Disponible en: https://doi.org/10.1016/j.numecd.2020.04.001

24. Bonow RO, Fonarow GC, O’Gara PT, Yancy CW. Association of Coronavirus Disease 2019 (COVID-19) With Myocardial Injury and Mortality. JAMA Cardiol [Internet]. 2020 [citado 24/4/2020] [article in press]. Disponible en: http://doi.org/10.1001/jamacardio.2020.1105

25. Bansal M. Cardiovascular disease and COVID-19. Diabetes & Metabolic Syndrome: Clinical Research & Reviews [Internet]. 2020 [citado 25/04/2020]; 14(2020): 247-250. Disponible en: https://doi.org/10.1016/j.dsx.2020.03.013

26. Wang D, Hu B, Hu C. Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China. JAMA [Internet]. 2020 [citado 25/05/2020]; 323(11):1061-1069. Disponible en: http://doi.org/10.1001/jama.2020.1585

27. Tang N, Li D, Wang X, Sun Z. Abnormal coagulation parameters are associated with por prognosis in patients with novel coronavirus pneumonia. J Thromb Haemost [Internet]. 2020 [citado 24/04/2020]; 00:1–4. Disponible desde: https://doi.org/10.1111/jth.14768

28. Atri D, Siddiqi HK, Lang J, Nauffal V, Morrow DA, Bohula EA, COVID-19 for the Cardiologist: A Current Review of the Virology, Clinical Epidemiology, Cardiac and Other Clinical Manifestations and Potential Therapeutic Strategies. JACC: Basic to Translational Science. 2020 [citado 26/04/2020]; [article in press]. Disponible en: https://doi.org/10.1016/j.jacbts.2020.04.002.

29. Xiong TY, Redwood S, Prendergast B, Chen M. Coronaviruses and the cardiovascular system: acute and long-term implications. European Heart Journal [Internet]. 2020 [citado 25/04/2020]; 2020(0):1–3. Disponible en: https://doi.org/10.1093/eurheartj/ehaa231

30. South AM, Diz DI, Mark C. COVID-19, ACE2, and the cardiovascular consequences. AJP-Heart Circ Physiol [Internet]. 2020 [citado 25/04/2020];318:H1084–H1090. Disponible en: https://doi.org/10.1152/ajpheart.00217.2020

31. Varejão Strabelli TM, Everson Uip D. COVID-19 and the Heart. Arq Bras Cardiol [Internet]. 2020 [citado 24/04/2020]; [article in press]. Disponible en: https://doi.org/10.36660/abc.20200209

32. Guo T, Fan Y, Chen M. Cardiovascular Implications of Fatal Outcomes of Patients With Coronavirus Disease 2019(COVID-19). JAMA Cardiol. [Internet]. 2020 [citado 24/4/2020]. Disponible en: http://doi.org/10.1001/jamacardio.2020.1017

33. Inciardi RM, Lupi L, Zaccone G. Cardiac Involvement in a Patient With Coronavirus Disease 2019 (COVID-19). JAMA Cardiol. [Internet]. 2020 [citado 24/4/2020]. Disponible en: http://doi.org/10.1001/jamacardio.2020.1096

34. Madjid M, Safavi-Naeini P, Solomon SD, Vardeny O. Potential Effects of Coronaviruses on the Cardiovascular System: A Review. JAMA Cardiol [Internet]. 2020 [citado 24/4/2020]. Disponible desde: http://doi.org/10.1001/jamacardio.2020.1286

35. Cabrera-Gaytán, David Alejandro; Vargas-Valerio, Alfredo; Grajales-Muñiz, Concepción Infección del nuevo coronavirus: nuevos retos, nuevos legados. Revista Médica del Instituto Mexicano del Seguro Social [Internet]. 2020 [citado 24/04/2020]; 52(4):438-441. Disponible en: http://www.redalyc.org/articulo.oa?id=457745483018

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Published

2020-05-21

How to Cite

1.
Gómez-Tejeda JJ, Hernandez-Perez C, Aguilera-Velazquez Y. Cardiovascular system involvement in SARS-CoV-2 infection. Univ. Méd. Pinareña [Internet]. 2020 May 21 [cited 2025 May 9];16(3):e521. Available from: https://revgaleno.sld.cu/index.php/ump/article/view/521

Issue

Vol. 16 No. 3 (2020): Septiembre-Diciembre

Section

Review article

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