Risk factors for the development of dental agenesis
DOI:
https://doi.org/10.5281/zenodo.8251096Keywords:
Anodontia, Risk Factors, Genetics, Ectodermal Dysplasia, Environment.Abstract
Introduction: dental agenesis is a disease characterized by the non-formation of some dental pieces, most frequently the lack of molars and upper lateral incisors. It affects not only the esthetics of people but also physiological processes such as feeding, so controlling the risk factors becomes a necessity.
Objective: to describe the risk factors for dental agenesis.
Method: a review of the literature was carried out in databases such as PubMed, Scopus, Cinhal and SciELO using the terms: hypodontia and anodontia, and their combination using the AND and OR operators and applying a temporal selection filter of the last 5 years.
Results: this pathology is divided into: anodontia, oligodontia, hypodontia; it can also be classified as syndromic and non-syndromic. According to some studies it can be caused by environmental risk factors, which trigger genetic elements, with involvement of PAX9, EDA, EDAR and MSX1 genes, product of a side effect of some medication ingested by the mother or also diseases such as Down Syndrome, and ectodermal dysplasia.
Conclusions: there are several factors involved in dental agenesis, which include genetics, the existence of congenital diseases, interaction with the environment, and factors related to the habits and lifestyles of the parents. It is suggested that evolution is an influential factor in this phenomenon.
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References
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17. Marzouk T, Alves IL, Wong CL, DeLucia L, McKinney CM, Pendleton C, et al. Association between Dental Anomalies and Orofacial Clefts: A Meta-analysis. JDR Clin Transl Res [Internet]. 2021 [citado 05/02/2023]; 6(4):368–81. Disponible en: http://journals.sagepub.com/doi/10.1177/2380084420964795
18. Anbouba GM, Carmany EP, Natoli JL. The characterization of hypodontia, hypohidrosis, and hypotrichosis associated with X‐linked hypohidrotic ectodermal dysplasia: A systematic review. Am J Med Genet Part A [Internet]. 2020 [citado 05/02/2023]; 182(4):831–41. Disponible en: https://onlinelibrary.wiley.com/doi/10.1002/ajmg.a.61493
19. Sir-Mendoza F, González-Martínez F, Madera M. Prevalence of KRAS, PIK3CA, BRAF and AXIN2 gene mutations in colorectal cancer and its relationship with dental agenesis: a systematic review. Rev la Fac Med [Internet]. 2021 [citado 05/02/2023]; 71(1):e95595. Disponible en: https://revistas.unal.edu.co/index.php/revfacmed/article/view/95595
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21. Mollo López J, Strauss Quintela M, Calderón Flores VH, Soto Mendoza K, Chambi Llusco M. Endodoncia y rehabilitación protésica como alternativa terapéutica de geminación dental. Rev Investig e Inf en Salud [Internet]. 2022 [citado 05/02/2023];17(42):23–31. Disponible en: https://revistas.univalle.edu/index.php/salud/article/view/221
22. Meade MJ, Dreyer CW. Tooth agenesis: An overview of diagnosis, aetiology and management. Jpn Dent Sci Rev [Internet]. 2023 [citado 05/02/2023]; 59:209–18. Disponible en: https://linkinghub.elsevier.com/retrieve/pii/S1882761623000182
23. Mattheeuws N. Has hypodontia increased in Caucasians during the 20th century? A meta-analysis. Eur J Orthod [Internet]. 2004 [citado 05/02/2023]; 26(1):99–103. Disponible en: https://academic.oup.com/ejo/article-lookup/doi/10.1093/ejo/26.1.99
2. Flores-Carrillo CL, Santiesteban-Ponciano FA, Gutiérrez-Rojo JF. Tratamiento de ortodoncia en paciente con agenesia de incisivos laterales superiores. Rev Tame [Internet]. 2019 [citado 05/02/2023]; 7(2021):842–7. Disponible en: https://www.medigraphic.com/cgi-bin/new/resumen.cgi?IDARTICULO=91398
3. Safari S, Ebadifar A, Najmabadi H, Kamali K, Abedini SS. Screening PAX9, MSX1 and WNT10A Mutations in 4 Iranian Families with Non-Syndromic Tooth Agenesis. Avicenna J Med Biotechnol [Internet]. 2020 [citado 05/02/2023]; 12(4):236–40. Disponible en: http://www.ncbi.nlm.nih.gov/pubmed/33014315
4. Jiménez-Sánchez AC, Sierra-Robles E. Frecuencia de agenesias dentales en pacientes que acudieron a un centro radiologico en Guadalajara, Mexico. Rev Tame [Internet]. 2019 [citado 05/02/2023]; 8(22):866. Disponible en: https://www.uan.edu.mx/d/a/publicaciones/revista_tame/numero_22/Tam1922-05i.pdf
5. Gosso C. Estudio preliminar de agenesias dentales, en pacientes de Córdoba-Argentina. Rev Fac Odontol Univ Nac (Cordoba) [Internet]. 2020 [citado 05/02/2023]; 30(1):e27820. Disponible en: https://revistas.unc.edu.ar/index.php/RevFacOdonto/article/view/27820
6. Yagnam Díaz K, Rozas Escobar I, Abdala Torres N, Monsalve Víctor R, Tapia Soler C. Prevalencia de agenesia dental en pacientes evaluados en ortodoncia, Santiago de Chile. Odontol Vital [Internet]. 2020 [citado 05/02/2023]; 32:57–62. Disponible en: https://www.scielo.sa.cr/scielo.php?script=sci_arttext&pid=S1659-07752020000100057
7. Abad Jiménez TL. Agenesia de terceros molares en pacientes atendidos en el quirófano de la Facultad de Odontología de la Universidad Central del Ecuador, en edades de entre 14 y 30 años [Tesis de Grado]. Quito: Universidad Central de Ecuador; 2022 [citado 05/02/2023]. Disponible en: http://www.dspace.uce.edu.ec/handle/25000/28332?mode=full
8. Gurrola-González EG, Zambrano-Galván G, Gómez-Palacio-Gastelum M, Barajas-Pérez VH. Detección polimórfica del rs104893850 de MSX1 y rs28933373 de PAX9 en personas con agenesia dental no sindrómica. Rev la Asoc Dent Mex [Internet]. 2022 [citado 05/02/2023]; 79(6):304–11. Disponible en: https://www.medigraphic.com/cgi-bin/new/resumen.cgi?IDARTICULO=108703
9. Yu M, Wong S, Han D, Cai T. Genetic analysis: Wnt and other pathways in nonsyndromic tooth agenesis. Oral Dis [Internet]. 2019 [citado 05/02/2023]; 25(3):646–51. Disponible en: https://onlinelibrary.wiley.com/doi/10.1111/odi.12931
10. Silva ID da, Luiz CCSP, Bachesk AB, Balassa B da S. Genetic bases related to the development of non-syndromic dental agenesis: a literature review. Res Soc Dev [Internet]. 2020 [citado 05/02/2023]; 9(11):e2449119882. Disponible en: https://rsdjournal.org/index.php/rsd/article/view/9882
11. Calheiros-Lobo MJ, Calheiros-Lobo M, Pinho T. Esthetic Perception of Different Clinical Situations of Maxillary Lateral Incisor Agenesis According to Populations with Dental and Non-Dental Backgrounds: A Systematic Review and Meta-Analysis. Dent J [Internet]. 2023 [citado 07/05/2023]; 11(4):105. Disponible en: https://www.mdpi.com/2304-6767/11/4/105
12. Do Brasil J de MT, Reis CLB, Küchler EC, De Menezes FCH, Bonilauri APR, Lepri CP, et al. ¿Is dental agenesis associated with sella turcica morphology? A systematic review. Brazilian J Heal Rev [Internet]. 2022 [citado 05/02/2023]; 5(1):1713–24. Disponible en: https://www.brazilianjournals.com/index.php/BJHR/article/view/43192
13. Rivas-Almonte UO, Cruz-Escalante MA, Delgado-Bocanegra CA. Retraso de la erupción dental en el síndrome de Down: evaluación crítica de la evidencia. Odontol Sanmarquina [Internet]. 2021 [citado 05/02/2023]; 24(1):45–51. Disponible en: https://revistasinvestigacion.unmsm.edu.pe/index.php/odont/article/view/18158
14. Kunz F, Kayserili H, Midro A, Silva D, Basnayake S, Güven Y, et al. Characteristic dental pattern with hypodontia and short roots in Fraser syndrome. Am J Med Genet Part A [Internet]. 2020 [citado 05/02/2023]; 182(7):1681–9. Disponible en: https://onlinelibrary.wiley.com/doi/10.1002/ajmg.a.61610
15. Sánchez Peña MK, Galvis Aricapa JA. Anomalías dentales de los pacientes con labio y paladar hendido. Rev Nac Odontol [Internet]. 2019 [citado 05/02/2023]; 16(1):1–17. Disponible en: https://revistas.ucc.edu.co/index.php/od/article/view/3343
16. Mayancela JL, Alvarado AL. Anomalías dentarias de número, presentes en pacientes con labio y paladar fisurado, de 6 a 12 años de edad. Revisión de literatura. Odontol Act Rev Científica [Internet]. 2021 [citado 05/02/2023]; 6(3):23–30. Disponible en: https://oactiva.ucacue.edu.ec/index.php/oactiva/article/view/620
17. Marzouk T, Alves IL, Wong CL, DeLucia L, McKinney CM, Pendleton C, et al. Association between Dental Anomalies and Orofacial Clefts: A Meta-analysis. JDR Clin Transl Res [Internet]. 2021 [citado 05/02/2023]; 6(4):368–81. Disponible en: http://journals.sagepub.com/doi/10.1177/2380084420964795
18. Anbouba GM, Carmany EP, Natoli JL. The characterization of hypodontia, hypohidrosis, and hypotrichosis associated with X‐linked hypohidrotic ectodermal dysplasia: A systematic review. Am J Med Genet Part A [Internet]. 2020 [citado 05/02/2023]; 182(4):831–41. Disponible en: https://onlinelibrary.wiley.com/doi/10.1002/ajmg.a.61493
19. Sir-Mendoza F, González-Martínez F, Madera M. Prevalence of KRAS, PIK3CA, BRAF and AXIN2 gene mutations in colorectal cancer and its relationship with dental agenesis: a systematic review. Rev la Fac Med [Internet]. 2021 [citado 05/02/2023]; 71(1):e95595. Disponible en: https://revistas.unal.edu.co/index.php/revfacmed/article/view/95595
20. Atanacio LA, Reyes WA. Hypodontia in Children: Importance and Risk Factors. Odovtos - Int J Dent Sci [Internet]. 2022 [citado 05/02/2023]; 24(3)10-11. Disponible en: https://revistas.ucr.ac.cr/index.php/Odontos/article/view/49849
21. Mollo López J, Strauss Quintela M, Calderón Flores VH, Soto Mendoza K, Chambi Llusco M. Endodoncia y rehabilitación protésica como alternativa terapéutica de geminación dental. Rev Investig e Inf en Salud [Internet]. 2022 [citado 05/02/2023];17(42):23–31. Disponible en: https://revistas.univalle.edu/index.php/salud/article/view/221
22. Meade MJ, Dreyer CW. Tooth agenesis: An overview of diagnosis, aetiology and management. Jpn Dent Sci Rev [Internet]. 2023 [citado 05/02/2023]; 59:209–18. Disponible en: https://linkinghub.elsevier.com/retrieve/pii/S1882761623000182
23. Mattheeuws N. Has hypodontia increased in Caucasians during the 20th century? A meta-analysis. Eur J Orthod [Internet]. 2004 [citado 05/02/2023]; 26(1):99–103. Disponible en: https://academic.oup.com/ejo/article-lookup/doi/10.1093/ejo/26.1.99
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Published
2023-08-11
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Haro-Amores VF, Vega-Camacho CN, Mullo-Auquilla VA, Lozada-López F del R. Risk factors for the development of dental agenesis. Univ. Méd. Pinareña [Internet]. 2023 Aug. 11 [cited 2025 Apr. 2];19:e987. Available from: https://revgaleno.sld.cu/index.php/ump/article/view/987
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