Pathogen- and damage-associated molecular patterns as molecular barriers to the immune response

Authors

Keywords:

PATHOGEN-ASSOCIATED MOLECULAR PATTERNS, MOLECULAR PATTERNS ASSOCIATED WITH DAMAGE, CELL DEATH.

Abstract

The principle of the functioning of the immune system is the recognition of foreign agents, foreign to the organism that must be neutralized and eliminated before they cause damage. The aim of the present work was to describe the essential aspects of the molecular patterns associated with pathogens and damage as molecular barriers of the immune response. A literature review was performed in the databases: PubMed, Scopus, Hinari, Elsevier, Medline and SciELO; 69 articles were evaluated, and 42 published in the last 5 years were selected including original and review articles in English and Spanish languages. Molecular aspects of the damage response are explained, from the recognition of an agent or damage, signaling pathways for cytokine release, vascular and cellular effects, to its resolution. The recognition of DAMPs and PAMPs as molecular barriers to the immune response is evident from their activity as promoters of the inflammatory response and their implications in cytokine activation as a host defense response and immunogenic cell death.

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Published

2024-11-30

How to Cite

1.
Dunán-Cala L. Pathogen- and damage-associated molecular patterns as molecular barriers to the immune response. Univ. Méd. Pinareña [Internet]. 2024 Nov. 30 [cited 2025 Apr. 19];20:e1045. Available from: https://revgaleno.sld.cu/index.php/ump/article/view/1045

Issue

Vol. 20 (2024): (Sistema de Publicación Continua)

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Review article

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