Ethiopathogenic factors influencing the development of basal cell carcinoma
Keywords:
Carcinoma, Basal Cell, Skin Neoplasms.Abstract
Introduction: basal cell carcinoma is a cutaneous neoplasm of high incidence, characterized by slow growth and low metastatic capacity.
Objective: to describe the ethiopathogenic factors that influence on the onset of basal cell carcinoma.
Methods: a search for information was carried out between November 2020 and January 2021 in PubMed, SciELO, ScienceDirect, Medigraphic and Scopus databases. A search strategy was employed by combining related terms using Boolean operators. Twenty-eight articles in Spanish and English were chosen.
Development: ultraviolet radiation is considered to be the main determinant in the development of basal cell carcinoma, where ultraviolet radiation type A is the one with the highest incidence. Photo-types I and II are determined to be more prone to the development of the disease. There is a genetic basis that confers susceptibility for the development of basal cell carcinoma. Patients with certain degrees of immunosuppression either by disease or by habits such as alcoholism are prone to develop the disease.
Conclusions: ultraviolet radiation, photo-type, genetic and immunological factors, heredity, consumption of substances such as arsenic, chlorophenols and immunosuppressive drugs, and exposure to ionizing radiation are ethiopathogenic factors that influence on the onset of basal cell carcinoma. Other factors such as poor access to preventive campaigns, health services and the media, as well as the increase in the population that does not make use of sun protection methods, may increase the risk of suffering from this disease.
Downloads
Download data is not yet available.
References
1. Álvarez Castillo A, Rodríguez Alfaro JM, Salas Boza A. Revisión sistemática del carcinoma basocelular. Rev Méd sinerg. [Internet]. 2020 [citado 3/01/2021]; 5(5):e483. Disponible en: https://revistamedicasinergia.com/index.php/rms/article/view/483
2. Díaz González L, Sánchez Acosta K, Maiquet Vega SA. Carcinoma basal en región nasal: tratamiento quirúrgico y reconstrucción con colgajo bilobilado. 16 de abril [Internet]. 2018 [citado 20/12/2020]; 57(269):201-206. Disponible en: http://www.rev16deabril.sld.cu/index.php/16_04/article/view/702
3. Tanese K. Diagnosis and Management of Basal Cell Carcinoma. Curr Treat Options [Internet]. 2019 [citado 20/12/2020]; 20(2):13. Disponible en: https://link.springer.com/article/10.1007/s11864-019-0610-0
4. Ferrá-Torres TM, Sánchez-Rodríguez E, Ballester-Caballero Y. Caracterización de pacientes con carcinoma basocelular tratados con HeberFERON. Rev Arch Méd Camagüey [Internet]. 2020 [citado 20/12/2020]; 24(2):10. Disponible en: http://revistaamc.sld.cu/index.php/amc/article/view/7136
5. Muzic J, Schmitt A, Wriht A, Alniemi DT, Zubair AS, Olazagasti Lourido J, et al. Incidence and Trends of Basal Cell Carcinoma and Cutaneous Squamous Cell Carcinoma: A Population-Based Study in Olmsted County, Minnesota, 2000 to 2010. Mayo Clin Proc [Internet]. 2017 [citado 3/01/2021]; 92(6):890-898. Disponible en: https://www.mayoclinicproceedings.org/article/S0025-6196(17)30164-7/fulltext
6. Bordelois Abdo JA, López Mateus M, Fernández Ramírez I, Lagos Ordoñez KJ. Caracterización del adulto mayor con diagnóstico probable de cáncer de piel. Rev. Inf. Cient. [Internet]. 2019 [citado 3/02/2021]; 98(1):7-16. Disponible en: http://www.revinfcientifica.sld.cu/index.php/ric/article/view/2194
7. Kelleners-Smeets NW, Mosterd K, Nelemans PJ. Treatment of Low-Risk Basal Cell Carcinoma. Journal of Investigative Dermatology [Internet]. 2017 [citado 20/12/2020]; 137(3):539-540. Disponible en: https://www.jidonline.org/article/S0022-202X(16)32765-8/fulltext
8. Cuevas González MV, Vega-Memije ME, Chairez-Atienzo P, García-Calderón AM. Frecuencia de cáncer de piel en un centro de diagnóstico histopatológico en la ciudad de Durango, Durango, México. Dermatol Rev Mex [Internet]. 2016 [citado 3/01/2021]; 60(1):11-17. Disponible en: https://dermatologiarevistamexicana.org.mx/article/frecuencia-de-cancer-de-piel-en-un-centro-de-diagnostico-histopatologico-en-la-ciudad-de-durango-durango-mexico/
9. Dirección de Registros Médicos y Estadística de salud. Anuario Estadístico de Salud 2019 [en línea]. La Habana: Ministerio de Salud Pública; 2020. [citado 03/05/2020]. Disponible en: http://files.sld.cu/bvscuba/files/2020/05/Anuario-Electr%C3%B3nico-Espa%C3%B1ol-2019-ed-
2020.pdf
10. Cameron MC, Lee E, Hibler B, Barker C, Mori S, Cordova M, et al. Basal cell carcinoma: Epidemiology; pathophysiology; clinical and histological subtypes; and disease associations. J Am Acad Dermatol. [Internet]. 2017 [citado 28/12/2020]; 80(2):303-317. Disponible en: https://www.jaad.org/article/S0190-9622(18)30775-8/fulltext
11. Bakshi A, Chaudhary S, Rana M, Elmets CA, Athar M. Basal cell carcinoma pathogenesis and therapy involving hedgehog signaling and beyond. Mol Carcinog [Internet]. 2017 [citado 26/12/2020]; 56(12):2543-57. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5962346/
12. Little MP, Linet MS, Kimlin MG, Lee T, Tatalovich Z, Sigurdson AJ, et al. Cumulative solar ultraviolet radiation exposure and basal cell carcinoma of the skin in a nationwide US cohort using satellite and groung-based measures. Environ Health [Internet]. 2019 [citado 30/12/2020]; 18(2019):114. Disponible en: https://ehjournal.biomedcentral.com/articles/10.1186/s12940-019-0536-9
13. Álava Cedeño MS, Herrera Álava JC, Montesdeoca Chancay AL, Macías Palma AM, Quijije Roldan J. Carcinoma basocelular como debut por exposición al sol. MEDICIENCIAS UTA [Internet]. 2020 [citado 22/12/2020]; 4(2):49-53. Disponible en: https://medicienciasuta.uta.edu.ec/index.php/MedicienciasUTA/article/view/331
14. Sordo C, Gutiérrez C. Cáncer de piel y radiación solar: experiencia peruana en la prevención y detección temprana del cáncer de piel y melanoma. Rev. Peru. Med. Exp. Salud Publica [Internet]. 2013 [citado 12/01/2021]; 30(1):113-117. Disponible en: https://www.redalyc.org/articulo.oa?id=36326085021
15. Roque Pérez L, González Escudero M, Pérez Acosta ND. Algunas características del cáncer de piel en pacientes del municipio Sagua la Grande. Medicent Electrón [Internet]. 2020 [citado 25/12/2020]; 24(1):165-163. Disponible en: http://www.medicentro.sld.cu/index.php/medicentro/article/view/2742/2516
16. Sánchez G, Nova J, de la Hoz F. Factores de riesgo de carcinoma basocelular. Un estudio del Centro Nacional de Dermatología del Colombia. Actas Dermosifiliogr. [Internet]. 2012 [citado 13/01/2021]; 103(4):294-230. Disponible en: https://www.actasdermo.org/es-factores-riesgo-carcinoma-basocelular-un-articulo-S0001731011004212
17. Kasumagic-Halilovic E, Hasic M, Ovcina-Kurtovic N. A Clinical Study of Basal Cell Carcinoma. Med Arch [Internet]. 2019 [citado 25/12/2020]; 73(6):394-398. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7007603/
18. Suárez Hernández J, Fernández-de-Misa Cabrera R. Etiopatogenia del carcinoma basocelular. Vías genéticas y dianas terapéuticas. Piel (BARC) [Internet]. 2015 [citado 22/12/2020]; 30(9):561-569. Disponible en: https://www.elsevier.es/es-revista-piel-formacion-continuada-dermatologia-21-articulo-etiopatogenia-del-carcinoma-basocelular-vias-S0213925115000738
19. Ahmad I, Munner K, Chang M, Nasr H, Clay J, Huang C, et al. Ultraviolet Radiation Induced Down-regulation of SERCA2 Mediates Activation of NLRP3 Inflammasome in Basall Cell Carcinoma. Phatochem Photobiol Sci [Internet]. 2018 [citado 21/12/2020]; 17(12):1872-1884. Disponible en: https://onlinelibrary.wiley.com/doi/full/10.1111/php.12725
20. Pellegrini C, Maturo MG, Di Nardo L, Ciciarelli V, Gutiérrez García-Rodrigo C, Fargnoli MC. Understanding the Molecular Genetics of Basal Cell Carcinoma. Int. J. Mol. Sci. [Internet]. 2017 [citado 3/01/2021]; 18(11):2485. Disponible en: https://www.mdpi.com/1422-0067/18/11/2485/htm
21. Monserrat García MT, Domínguez Cruz JJ, Conejo-Mir J. Carcinoma basocelular: biología molecular y nuevas dianas terapéuticas. Med Cutan Iber Lat Am [Internet]. 2016 [citado 5/01/2021]; 44(2):89-99. Disponible en: https://dialnet.unirioja.es/servlet/articulo?codigo=5704225
22. Maturo MG, Rachakonda S, Heidenreich B, Pellegrini B, Srinivas N, Requena C. Coding and noncoding somatic mutations in candidate genes in basal cell carcinoma. Sci Rep [Internet]. 2020 [citado 12/01/2021]; 10(2020):8005. Disponible en: https://www.nature.com/articles/s41598-020-65057-2#citeas
23. Lang BM, Balermpas P, Bauer A, Blum A, Brölsch F, Dirschka T, et al. S2k Guidelines for Cutaneous Basal Cell Carcinoma - Part 1: Epidemiology, Genetics and Diagnosis. JDDG [Internet]. 2019 [citado 20/01/2021]; 17(1):94-103. Disponible en: https://www.onlinelibrary.wiley.com/doi/full/10.1111/ddg.13733
24. Lang BM, Balermpas P, Bauer A, Blum A, Brölsch F, Dirschka T, et al. S2k Guidelines for Cutaneous Basal Cell Carcinoma - Part 2: Treatment, Prevention and Follow-up. JDDG [Internet]. 2019 [citado 20/01/2021]; 17(2):214-230. Disponible en: https://www.onlinelibrary.wiley.com/doi/full/10.1111/ddg.13755
25. Williams H, Bath-Hextall F, Ozolins M, Armstrong S, Colver G, Perkins W, et al. Surgery Versus 5% Imiquimod for Nodular and Superficial Basal Cell Carcinoma: 5-Year Results of the SINS Randomized Controlled Trial. Journal of Investigative Dermatology [Internet]. 2017 [citado 20/12/2020]; 137(3):614-619. Disponible en: https://www.jidonline.org/article/S0022-202X(16)32538-6/fulltext
26. Yen H, Dhana A, Okhovat P, Quereshi A, Kneum N, Cho E. Alcohol intake and risk of nomelanoma skin cancer: a systematic review and dose-response meta-analysis. Br J Dermatol [Internet]. 2017 [citado 1/4/2021]; 177(2017):696-707. Disponible en: https://onlinelibrary.wiley.com/doi/full/10.1111/bdj.15647
27. Deniz Demirseren D, Cicek C, Alisik M, Demirseren ME, Aktas A, Erel O. Dynamic Thiol/Disulphide Homeostasis in patients with Basal Cell Carcinoma. Turk J Gastroenterol [Internet]. 2018 [citado 23/12/2020]; 29(3):248-283. Disponible en: https://www.tandfonline.com/doi/full/10.1080/15569527.2016.1268150?scroll=top&needAccess=true
28. Galimberti RL, Rodríguez Chiapetta MF, Ferrario D, Galimberti NG. Inmunosupresores y cáncer de piel. Rev Dermatol Argent [Internet]. 2010 [citado 1/4/2021]; 16(4):279-282. Disponible en: https://www.dermatolarg.org.ar/index.php/dermatolarg/article/view/404
2. Díaz González L, Sánchez Acosta K, Maiquet Vega SA. Carcinoma basal en región nasal: tratamiento quirúrgico y reconstrucción con colgajo bilobilado. 16 de abril [Internet]. 2018 [citado 20/12/2020]; 57(269):201-206. Disponible en: http://www.rev16deabril.sld.cu/index.php/16_04/article/view/702
3. Tanese K. Diagnosis and Management of Basal Cell Carcinoma. Curr Treat Options [Internet]. 2019 [citado 20/12/2020]; 20(2):13. Disponible en: https://link.springer.com/article/10.1007/s11864-019-0610-0
4. Ferrá-Torres TM, Sánchez-Rodríguez E, Ballester-Caballero Y. Caracterización de pacientes con carcinoma basocelular tratados con HeberFERON. Rev Arch Méd Camagüey [Internet]. 2020 [citado 20/12/2020]; 24(2):10. Disponible en: http://revistaamc.sld.cu/index.php/amc/article/view/7136
5. Muzic J, Schmitt A, Wriht A, Alniemi DT, Zubair AS, Olazagasti Lourido J, et al. Incidence and Trends of Basal Cell Carcinoma and Cutaneous Squamous Cell Carcinoma: A Population-Based Study in Olmsted County, Minnesota, 2000 to 2010. Mayo Clin Proc [Internet]. 2017 [citado 3/01/2021]; 92(6):890-898. Disponible en: https://www.mayoclinicproceedings.org/article/S0025-6196(17)30164-7/fulltext
6. Bordelois Abdo JA, López Mateus M, Fernández Ramírez I, Lagos Ordoñez KJ. Caracterización del adulto mayor con diagnóstico probable de cáncer de piel. Rev. Inf. Cient. [Internet]. 2019 [citado 3/02/2021]; 98(1):7-16. Disponible en: http://www.revinfcientifica.sld.cu/index.php/ric/article/view/2194
7. Kelleners-Smeets NW, Mosterd K, Nelemans PJ. Treatment of Low-Risk Basal Cell Carcinoma. Journal of Investigative Dermatology [Internet]. 2017 [citado 20/12/2020]; 137(3):539-540. Disponible en: https://www.jidonline.org/article/S0022-202X(16)32765-8/fulltext
8. Cuevas González MV, Vega-Memije ME, Chairez-Atienzo P, García-Calderón AM. Frecuencia de cáncer de piel en un centro de diagnóstico histopatológico en la ciudad de Durango, Durango, México. Dermatol Rev Mex [Internet]. 2016 [citado 3/01/2021]; 60(1):11-17. Disponible en: https://dermatologiarevistamexicana.org.mx/article/frecuencia-de-cancer-de-piel-en-un-centro-de-diagnostico-histopatologico-en-la-ciudad-de-durango-durango-mexico/
9. Dirección de Registros Médicos y Estadística de salud. Anuario Estadístico de Salud 2019 [en línea]. La Habana: Ministerio de Salud Pública; 2020. [citado 03/05/2020]. Disponible en: http://files.sld.cu/bvscuba/files/2020/05/Anuario-Electr%C3%B3nico-Espa%C3%B1ol-2019-ed-
2020.pdf
10. Cameron MC, Lee E, Hibler B, Barker C, Mori S, Cordova M, et al. Basal cell carcinoma: Epidemiology; pathophysiology; clinical and histological subtypes; and disease associations. J Am Acad Dermatol. [Internet]. 2017 [citado 28/12/2020]; 80(2):303-317. Disponible en: https://www.jaad.org/article/S0190-9622(18)30775-8/fulltext
11. Bakshi A, Chaudhary S, Rana M, Elmets CA, Athar M. Basal cell carcinoma pathogenesis and therapy involving hedgehog signaling and beyond. Mol Carcinog [Internet]. 2017 [citado 26/12/2020]; 56(12):2543-57. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5962346/
12. Little MP, Linet MS, Kimlin MG, Lee T, Tatalovich Z, Sigurdson AJ, et al. Cumulative solar ultraviolet radiation exposure and basal cell carcinoma of the skin in a nationwide US cohort using satellite and groung-based measures. Environ Health [Internet]. 2019 [citado 30/12/2020]; 18(2019):114. Disponible en: https://ehjournal.biomedcentral.com/articles/10.1186/s12940-019-0536-9
13. Álava Cedeño MS, Herrera Álava JC, Montesdeoca Chancay AL, Macías Palma AM, Quijije Roldan J. Carcinoma basocelular como debut por exposición al sol. MEDICIENCIAS UTA [Internet]. 2020 [citado 22/12/2020]; 4(2):49-53. Disponible en: https://medicienciasuta.uta.edu.ec/index.php/MedicienciasUTA/article/view/331
14. Sordo C, Gutiérrez C. Cáncer de piel y radiación solar: experiencia peruana en la prevención y detección temprana del cáncer de piel y melanoma. Rev. Peru. Med. Exp. Salud Publica [Internet]. 2013 [citado 12/01/2021]; 30(1):113-117. Disponible en: https://www.redalyc.org/articulo.oa?id=36326085021
15. Roque Pérez L, González Escudero M, Pérez Acosta ND. Algunas características del cáncer de piel en pacientes del municipio Sagua la Grande. Medicent Electrón [Internet]. 2020 [citado 25/12/2020]; 24(1):165-163. Disponible en: http://www.medicentro.sld.cu/index.php/medicentro/article/view/2742/2516
16. Sánchez G, Nova J, de la Hoz F. Factores de riesgo de carcinoma basocelular. Un estudio del Centro Nacional de Dermatología del Colombia. Actas Dermosifiliogr. [Internet]. 2012 [citado 13/01/2021]; 103(4):294-230. Disponible en: https://www.actasdermo.org/es-factores-riesgo-carcinoma-basocelular-un-articulo-S0001731011004212
17. Kasumagic-Halilovic E, Hasic M, Ovcina-Kurtovic N. A Clinical Study of Basal Cell Carcinoma. Med Arch [Internet]. 2019 [citado 25/12/2020]; 73(6):394-398. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7007603/
18. Suárez Hernández J, Fernández-de-Misa Cabrera R. Etiopatogenia del carcinoma basocelular. Vías genéticas y dianas terapéuticas. Piel (BARC) [Internet]. 2015 [citado 22/12/2020]; 30(9):561-569. Disponible en: https://www.elsevier.es/es-revista-piel-formacion-continuada-dermatologia-21-articulo-etiopatogenia-del-carcinoma-basocelular-vias-S0213925115000738
19. Ahmad I, Munner K, Chang M, Nasr H, Clay J, Huang C, et al. Ultraviolet Radiation Induced Down-regulation of SERCA2 Mediates Activation of NLRP3 Inflammasome in Basall Cell Carcinoma. Phatochem Photobiol Sci [Internet]. 2018 [citado 21/12/2020]; 17(12):1872-1884. Disponible en: https://onlinelibrary.wiley.com/doi/full/10.1111/php.12725
20. Pellegrini C, Maturo MG, Di Nardo L, Ciciarelli V, Gutiérrez García-Rodrigo C, Fargnoli MC. Understanding the Molecular Genetics of Basal Cell Carcinoma. Int. J. Mol. Sci. [Internet]. 2017 [citado 3/01/2021]; 18(11):2485. Disponible en: https://www.mdpi.com/1422-0067/18/11/2485/htm
21. Monserrat García MT, Domínguez Cruz JJ, Conejo-Mir J. Carcinoma basocelular: biología molecular y nuevas dianas terapéuticas. Med Cutan Iber Lat Am [Internet]. 2016 [citado 5/01/2021]; 44(2):89-99. Disponible en: https://dialnet.unirioja.es/servlet/articulo?codigo=5704225
22. Maturo MG, Rachakonda S, Heidenreich B, Pellegrini B, Srinivas N, Requena C. Coding and noncoding somatic mutations in candidate genes in basal cell carcinoma. Sci Rep [Internet]. 2020 [citado 12/01/2021]; 10(2020):8005. Disponible en: https://www.nature.com/articles/s41598-020-65057-2#citeas
23. Lang BM, Balermpas P, Bauer A, Blum A, Brölsch F, Dirschka T, et al. S2k Guidelines for Cutaneous Basal Cell Carcinoma - Part 1: Epidemiology, Genetics and Diagnosis. JDDG [Internet]. 2019 [citado 20/01/2021]; 17(1):94-103. Disponible en: https://www.onlinelibrary.wiley.com/doi/full/10.1111/ddg.13733
24. Lang BM, Balermpas P, Bauer A, Blum A, Brölsch F, Dirschka T, et al. S2k Guidelines for Cutaneous Basal Cell Carcinoma - Part 2: Treatment, Prevention and Follow-up. JDDG [Internet]. 2019 [citado 20/01/2021]; 17(2):214-230. Disponible en: https://www.onlinelibrary.wiley.com/doi/full/10.1111/ddg.13755
25. Williams H, Bath-Hextall F, Ozolins M, Armstrong S, Colver G, Perkins W, et al. Surgery Versus 5% Imiquimod for Nodular and Superficial Basal Cell Carcinoma: 5-Year Results of the SINS Randomized Controlled Trial. Journal of Investigative Dermatology [Internet]. 2017 [citado 20/12/2020]; 137(3):614-619. Disponible en: https://www.jidonline.org/article/S0022-202X(16)32538-6/fulltext
26. Yen H, Dhana A, Okhovat P, Quereshi A, Kneum N, Cho E. Alcohol intake and risk of nomelanoma skin cancer: a systematic review and dose-response meta-analysis. Br J Dermatol [Internet]. 2017 [citado 1/4/2021]; 177(2017):696-707. Disponible en: https://onlinelibrary.wiley.com/doi/full/10.1111/bdj.15647
27. Deniz Demirseren D, Cicek C, Alisik M, Demirseren ME, Aktas A, Erel O. Dynamic Thiol/Disulphide Homeostasis in patients with Basal Cell Carcinoma. Turk J Gastroenterol [Internet]. 2018 [citado 23/12/2020]; 29(3):248-283. Disponible en: https://www.tandfonline.com/doi/full/10.1080/15569527.2016.1268150?scroll=top&needAccess=true
28. Galimberti RL, Rodríguez Chiapetta MF, Ferrario D, Galimberti NG. Inmunosupresores y cáncer de piel. Rev Dermatol Argent [Internet]. 2010 [citado 1/4/2021]; 16(4):279-282. Disponible en: https://www.dermatolarg.org.ar/index.php/dermatolarg/article/view/404
Downloads
Published
2021-06-03
How to Cite
1.
Pena-Olivera RA, Navarro-Baldellot AL, Espín-Guerra L. Ethiopathogenic factors influencing the development of basal cell carcinoma. Univ. Méd. Pinareña [Internet]. 2021 Jun. 3 [cited 2025 Mar. 31];18(3):e668. Available from: https://revgaleno.sld.cu/index.php/ump/article/view/668
Issue
Section
Review article
