Polypharmacy and pharmacological adherence in adults at “Louis Pasteur” Teaching Polyclinic

Authors

Keywords:

Polypharmacy, Drug Combinations, Medication Adherence, Treatment Adherence and Compliance, Aged.

Abstract

Introduction: polypharmacy constitutes a phenomenon with significant consequences, therefore the importance of recognizing its risk factors.

Objective: to determine the factors associated with polypharmacy and its impact on therapeutic adherence in adults.

Methods: observational, analytical and cross-sectional study in patients from Number 10 Family Doctor’s Office at “Louis Pasteur” Teaching Polyclinic, between January and March 2021. The population comprised 222 patients, and the sample included 106 patients chosen by simple random sampling. Descriptive and inferential statistics was applied.

Results: predominance of patients from 70 years old or older (42,27 %) and average poly-medication (42,27 %). Self-medication was found in 77,4 % of patients. A total of 58,49 % of the population attended two or more inter-consultations and 33,01 % presented adverse drug reactions. Hypertension (77,32 %) and diabetes (27,84 %) predominated as comorbidities. Adherence was higher in ocular diseases and lower in oncologic diseases (100 %). An association was identified between major polypharmacy and unemployment (OR:3,37; CI:1,05-10,74; p=0,033), two or more comorbidities (OR:1,52; CI:1,28-1,8; p<0,01), adverse reactions (OR:5,17; CI:1,96-13,6; p<0,01), and two or more inter-consultations (OR:25,36; CI:3,27-196,68; p<0,01).

Conclusions: polypharmacy was frequent mainly in older adults with hypertension and diabetes mellitus as underlying diseases. Unemployment, the presence of two or more comorbidities, two or more inter-consultations and the occurrence of adverse reactions favored polypharmacy. 

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References

1. Homero Gace E. Polifarmacia y morbilidad en adultos mayores. Rev. Med. Clin. Condes. [Internet]. 2012 [citado 21/01/2021]; 23(1): 31-35. Disponible en: http://doi.org/10.1016/S0716-8640(12)70270-5.

2. Ramírez PAR, Ramírez PJF, Borrell ZJC. Polifarmacia e interacciones medicamentosas potenciales en el adulto mayor, una polémica en la prescripción. Rev Cubana Farm. [Internet]. 2019 [citado 21/01/2021]; 52(2):1-15. Disponible en: https://www.medigraphic.com/cgibin/new/resumen.cgi?IDARTICULO=93935

3. Dominguez Ives Y. Evaluación de prescripciones inadecuadas en pacientes de la tercera edad [Tesis]. Córdoba: Universidad Católica de Córdoba; 2017. Disponible en: http://pa.bibdigital.uccor.edu.ar/1562/1/TF_Dominguez_Ives.pdf

4. Hernández Ugalde F, Álvarez Escobar MD, Martínez Leyva G, Junco Sánchez VL, Valdés Gasmury I, Hidalgo Ruiz M. Polifarmacia en el anciano. Retos y soluciones. Rev medica electronica [Internet]. 2018 [citado 21/01/2021]; 40(6): [aprox. -2070 p.]. Disponible en: http://www.revmedicaelectronica.sld.cu/index.php/rme/article/view/2640

5. Sanabria C, Guzmán F. Adherencia farmacoterapéutica en pacientes geriátricos del Hospital Santa Bárbara in Sucre - Bolivia. Rev. Cien. Tec. In.[Internet]. 2018 [citado 21/01/2021]; 16(17):983-990. Disponible en: http://www.scielo.org.bo/scielo.php?script=sci_arttext&pid=S222587872018000100003&lng=es&nrm=iso

6. Organización Mundial de la Salud. Informe Mundial sobre el Envejecimiento y la Salud. Ginebra. OMS [Internet]. 2015 [citado21/01/2021]. Disponible en: https://www.who.int/ageing/publications/world-report-2015/es/

7. Ministerio de Salud Pública. Dirección de Registros Médicos y Estadísticas de Salud. Anuario Estadístico de Salud 2019. [Internet] La Habana, 2020 [citado 21/01/2021]. Disponible en: http://files.sld.cu/bvscuba/files/2020/05/Anuario-Electr%C3%B3nico-Espa%C3%B1ol-2019-ed-2020.pdf

8. Morisky D, Ang A, Krousel-Wood M, Ward H. Predictive Validity of A Medication Mesasure in an Outpatient Setting. J Clini Hypertens. [Internet]. 2008 [citado 29/03/2021]; 10(5):348-354. Disponible en: http://doi.org/10.1111/j.1751-7176.2008.07572.x.

9. González Casanova JM, Machado Ortiz FO, Casanova Moreno MC, Machado Reyes F. Polifarmacia en los adultos mayores del policlínico Hermanos Cruz. Univ Méd Pinareña [Internet]. 2019 [citado 21/01/2021]; 15(3):329-337. Disponible en: http://www.revgaleno.sld.cu/index.php/ump/article/view/359

10. Da Silva Córralo V, Marconatto Binotto V, Bohnen L, Gonzaga dos Santos GA, De-SáClodoaldo A. Factores asociados con la polifarmacia en los ancianos diabéticos. Rev. Salud pública [Internet]. 2018 [citado 25/01/2021]; 20(3):366-372. Disponible en: http://www.scielo.org.co/scielo.php?script=sci_arttext&pid=S012400642018000300366&lng=en

11. Ramírez Pérez A, Cisneros Nápoles Y, Castellanos González M, Ramírez Pérez J, Bórrelo Zayas J. Polifarmacia y complejidad farmacoterapéutica en pacientes de hogares de ancianos en Cienfuegos. Una evaluación desde la comunidad. Rev. Haban cienc méd. [Internet]. 2021 [citado 24/01/2021]; 20(3):e3646. Disponible en: http://www.revhabanera.sld.cu/index.php/rhab/article/view/3643

12. Gort Hernández M, Guzmán Carballo NM, Mesa Trujillo D, Miranda Jerez PA, Espinosa Ferro Y. Caracterización del consumo de medicamentos en el adulto mayor. Rev Cubana Med Gen Integr [Internet]. 2019 [citado 27/01/2021] ; 35(4):e970. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0864-21252019000400010&lng=es

13. Pereira KG, Peres MA, Lop D, Boing AC, Boing AF, Aziz M, et al. Polypharmacy among the elderly: a population-based study. Rev Bras Epidemiol. [Internet]. 2017 [citado 27/01/2021]; 20(2):335-344. Disponible en: https://doi.org/10.1590/1980-5497201700020013

14. Martínez Arroyo JL, Gómez García A, Sauceda Martínez D. Prevalencia de la polifarmacia y la prescripción de medicamentos inapropiados en el adulto mayor hospitalizado por enfermedades cardiovasculares. Gac. Méd. De Méx. [Internet]. 2014 [citado 29/01/2021]; 150(1):29-38. Disponible en: https://www.medigraphic.com/pdfs/gaceta/gm-2014/gms141d

15. Red de apoyo a la gestión educativa [Internet]. La Habana: Ministerio de Educación Superior; 2020 [citado 27/01/2021]. Disponible en: http://www.redage.org/instituciones/ministerio-de-educacion-superior
16. Ramírez PA, Furones Mourelle J, Cedeño Ramos A. Deprescripción en el anciano polimedicado. Una mirada reflexiva en el contexto cubano. Rev haban cienc méd [Internet]. 2020 [citado 27/01/2021] ; 19(3):e3416. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1729519X2020000300012&lng=es.

17. Cala Calviño L, Casas Gross S, Dunán Cruz LK. Efecto cascada en el anciano como consecuencia de la polifarmacia. MEDISAN [Internet]. 2017 [citado 27/01/2021]; 21(3):279-286. Disponible en: http://scielo.sld.cu/scielo.ph?script=sci_arttext&pid=S102930192017000300006&lng=es.

18. García-Orihuela M, Suárez-Conejero A, Otero-Morales J, Alfonso-Orta I, Caballero-Conesa G. Génesis de la polifarmacia y las prescripciones inapropiadas STOPP en ancianos. Anal. de la Acad. De Cienc. De Cuba [Internet]. 2020 [citado 29/01/2021]; 10(3): [aprox. 0 p.]. Disponible en: http://www.revistaccuba.cu/index.php/revacc/article/view/925

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Published

2021-08-24

How to Cite

1.
Jiménez-Pérez M de la C, Caballero-Cruz G, Góngora-Valdés J, Iglesias-Sordo G, Galardy-Díaz J. Polypharmacy and pharmacological adherence in adults at “Louis Pasteur” Teaching Polyclinic. Univ. Méd. Pinareña [Internet]. 2021 Aug. 24 [cited 2025 Apr. 13];17(2):e730. Available from: https://revgaleno.sld.cu/index.php/ump/article/view/730

Issue

Vol. 17 No. 2 (2021): Mayo-Agosto

Section

Original Article

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