Update on Still's Disease in Adults
DOI:
https://doi.org/10.5281/zenodo.7888333Keywords:
Adult Still's Disease, Juvenile Arthritis, Major Histocompatibility ComplexAbstract
Introduction: Still's disease occurs in children and adults, it is a multisystem autoinflammatory and autoimmune disorder, also called autoinflammatory polygenic syndrome.
Objective: to clinically and epidemiologically characterize Still's disease in adults.
Methods: a narrative review of the available literature was carried out using the synthetic analytical and historical-logical methods by means of articles retrieved from databases such as SciELO, Scopus and ClinicalKey. Filters were used for the selection of articles in English and Spanish languages; as well as articles published in the period 2018 to 2023.
Results: it is known that ASD is a more severe version of juvenile idiopathic arthritis occurring in children. Still's syndrome has no proven genetic background, however, it associates some histocompatibility complex antigens, mainly haploid HLA-specific. Contradictorily to the lack of genetic factor, the incidence of Still's disease or Still's syndrome is higher in women than in male patients. At the same time, the 2 phenotypes of the disease should be considered: acute systemic febrile disease with monocytic or polycyclic course (causing death) and chronic arthritis.
Conclusions: Still's disease usually appears in the first years of life. Its clinical and laboratory behavior, as well as the fulfillment of the classification criteria of the disease, facilitate its diagnosis, being differential broad and complex, Still's syndrome remains one of the medical problems of diagnosis and therapy with serious conditions.
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References
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