Hypomelanosis of Ito: case report

Authors

  • Osmel Mollinedo-Rangel Universidad de Ciencias Médicas de Villa Clara Facultad de Ciencias Médicas de Sagua la Grande. Villa Clara
  • Anays Tania Acuña-Amador Universidad de Ciencias Médicas de Villa Clara Facultad de Ciencias Médicas de Sagua la Grande. Villa Clara
  • Yendry Mederos-Benítez Universidad de Ciencias Médicas de Villa Clara. Hospital Materno Provincial "Mariana Grajales". Villa Clara https://orcid.org/0000-0002-4877-2398

Keywords:

Pigmentation Disorders, Hypopigmentation, Congenital Abnormalities

Abstract

Introduction: hypomelanosis of Ito is a neurocutaneous syndrome and a multisystem disorder, described by Japanese dermatologist Minor Ito in 1951. This disease is characterized by hypopigmented lesions of linear or annular distribution on the skin, associated or not with neurological and ocular manifestations, as well as dental and musculoskeletal malformations.

Case report: 12-year-old male patient, son of young non-blood parents with a family history of vagal crises, personality disorders and epileptic seizures in childhood. Personal pathological history included right unilateral appendageal since birth, spasms during sleep at 3 months, joint hyperlaxity and hypotonia at one year, delayed psychomotor development, focal temporal lobe and tonic-clonic epilepsy seizures at 10 years old, diagnosis of right pectoral agenesis at 1 year old and bilateral pyelectasis. He attended the Provincial Clinical Genetics Service referred by the Dermatology Clinic for presenting hypopigmented macules in the upper right limb, accompanied by the neurological, musculoskeletal and genitourinary signs described above. Taking into account the international criteria based on cutaneous and extra cutaneous manifestations, hypomelanosis of Ito was diagnosed.

Conclusions: hypomelanosis of Ito is a rare, multisystem disorder, with a fundamental clinical diagnosis. Early diagnosis is essential in order to provide a timely treatment, as well as knowing the forms of presentation and manifestations, achieving a better quality of life for the patient.

Downloads

Download data is not yet available.

References

1. Luna-Ceballos E, Perdomo-Arrién J, Sainz-Padrón L, Sainz-Padrón L. Asociación de hipomelanosis de Ito y paquioniquia congénita. Rev Cubana Gen Com [Internet]. 2019 [citado 11/05/2020]; 12(3): e76. Disponible en: http://revgenetica.sld.cu/index.php/gen/article/view/76

2. Projna Biswas, Abhishek De, Dayamay Pal, Asad Ansari, Sudip Das. Twin‑spot Phenomenon: A Rare Association Hypomelanosis of Ito with Nevoid Hypertrichosis. Indian Journal of Paediatric Dermatology [Internet]. 2018 [citado 11/05/2020]; 19(1): 88-90. Disponible en: http://www.ijpd.in/temp/IndianJPaediatrDermatol19188-8109752_223137.pdf

3. Romero A, Salazar M, Tufino M, Villacís A, Galarza F. Hipomelanosis de Ito. Dermatol Rev Mex [Internet]. 2015 [citado 11/05/2020]; 59: 43-8. Disponible en: http://www.medigraphic.com/pdfs/derrevmex/rmd-2015/rmd151g.pdf

4. Prudencio Beltrán R, López Loayza F, Flores Leque A, Siles Arias I. Hipomelanosis de Ito. Arch Boli de Med [Internet]. 2015 [citado 11/05/2020]; 23(91): 69-74. Disponible en: http://www.revistasbolivianas.org.bo/pdf/abm/v23n91/a08v23n91.pdf

5. Zamudio-Martínez G, Zamudio-Martínez A, Hernández-Arriaga P, Luna-Macías VB, Rizo-Jiménez A. Mosaicismo pigmentario del tipo hipomelanosis de Ito con hemimegalencefalia. Acta Pediatr Mex [Internet]. 2019 [citado 11/05/2020]; 40 (4): 217-222. Disponible en: http://ojs.actapediatrica.org.mx/index.php/APM/article/view/1853/1143

6. Naranjo MA, Torres M, Gómez MB. Hipomelanosis de Ito: reporte de caso. Rev Asoc Colomb Dermatol [Internet]. 2019 [citado 11/05/2020]; 27 (2): 128-132. Disponible en: https://revista.asocolderma.org.co/index.php/asocolderma/article/view/984

7. Licourt Otero D, Núñez Milián PS, Labrador Rodríguez E, Contreras Contreras Y, Díaz Hernández IA. Hipomelanosis de Ito. Presentación de un caso. Rev Ciencias Médicas [Internet]. 2011 [citado 11/05/2020]; 15 (2): 281-288. Disponible en: http://revcmpinar.sld.cu/index.php/publicaciones/article/view/779/1459

8. Ruiz-Maldonado R, Toussaint S, Tamayo L, Laterza A, del Castillo V. Hypomelanosis of Ito: Diagnostic
criteria and report of 41 cases. Pediatr Dermatol. 1992; 9:1-10.

9. Velázquez Ávila Y, Morales Solís M, Rodríguez Gundin R. Patrón cutáneo pigmentario de disposición lineal en un niño, vitíligo segmentario vs. hipomelanosis de Ito. Rev Cub Pediatr [Internet]. 2018 [citado 11/05/2020]; 90(3). Disponible en: http://www.revpediatria.sld.cu/index.php/ped/article/view/519/215

10. Koehler M. Hypomelanosis of ito in two infants: a case series with literature review. J Am Osteopath Col Derm [Internet]. 2015 [citado 11/05/2020]; 32: 49-51. https://cdn.ymaws.com/www.aocd.org/resource/resmgr/jaocd/contents/volume32/32-14.pdf

Downloads

Published

2020-05-28

How to Cite

1.
Mollinedo-Rangel O, Acuña-Amador AT, Mederos-Benítez Y. Hypomelanosis of Ito: case report. Univ. Méd. Pinareña [Internet]. 2020 May 28 [cited 2025 Apr. 19];16(3):e424. Available from: https://revgaleno.sld.cu/index.php/ump/article/view/424

Issue

Vol. 16 No. 3 (2020): Septiembre-Diciembre

Section

Case report

License

Authors who have published with this journal accept the following terms: authors will retain their copyright and guarantee the journal the right of first publication of their work, which will be simultaneously subject to the Creative Commons recognition license that allows third parties to share the work as long as its author is indicated and its first publication is this journal. Authors may adopt other non-exclusive license agreements for the distribution of the version of the published article (e.g., deposit it in an institutional telematic archive or publish it in a monographic volume) provided that the initial publication in this journal is indicated. Authors are permitted and encouraged to disseminate their article using Internet (e.g., in institutional telematic archives or on their website) before and during the submission process, which may lead to interesting exchanges and increased citations of the published work. (See The Effect of Open Access).

Most read articles by the same author(s)