Considerations on the treatment of Wilms’ tumor
Keywords:
Wilms Tumor, Kidney Neoplasms, Nephrectomy, Pediatric AssistantsAbstract
Introduction: Wilms’ tumor is the most common renal neoplasm in childhood, which makes it necessary to be updated in terms of its treatment.
Objective: to describe the treatment of Wilms’ tumor.
Method: a literature review was carried out in the Web of Science, Scopus, PubMed, ClinicalKey and SciELO databases. The search strategy used was a combination of terms, using the name of the disease and treatments. Twenty-six references were chosen.
Development: Wilms’ tumor represents a malignant tumor with a high cure rate; which is possible thanks to the development of surgical techniques, application of chemotherapy and recognition of the role of radiotherapy. These techniques used rationally have a great impact on the survival rate to this neoplasm. A fundamental pillar in the management of this entity is nephrectomy. There are two positions according to the moment of treatment with chemotherapy; before and after the surgical procedure. Radiotherapy is another modality in the treatment of nephroblastoma; it is used in advanced stages or in conditions where there are associated risk factors.
Conclusions: the treatment of Wilms’ tumor depends on the histological classification and staging. Its treatment is multidisciplinary and includes the combination of surgery, chemotherapy and radiotherapy. The application of the existing therapeutic protocols, as long as the parameters they establish are maintained, will have successful results in spite of the different sequences in which the therapeutic modalities are used.
Downloads
Download data is not yet available.
References
1. Valdés Martín S, Gómez Vasallo A, Báez Martínez JM. Temas de Pediatría. 2da ed. La Habana: ECIMED, 2011; p. 362.
2. Mirabal Fariñas A, Yalcouye H, Pantoja Blanco M, Cobas Landeau C, Romero García LI. Características clinicoterapéuticas de niños y adolescentes con neoplasias renales. MEDISAN [Internet]. 2015 [citado 10/03/2020]; 19(7): 821-30. Disponible en: http://www.medisan.sld.cu/index.php/san/article/view/378/html_101
3. Quero-Hernández A, Hernández Arriola J, Reyes Gómez U, Álvarez Solís RM, Vargas M, Tenorio Rodríguez H. Tumor de Wilms. Características clínicas y resultados del tratamiento. Pediat Mex [Internet]. 2011 [citado 10/03/2020]; 13(3): 109-113. Disponible en: http://www.medigraphic.com/pdfs/conapeme/pm-2011/pm113e.pdf
4. Rojas Barrantes EI. Tumor de Willms. Rev Med Costa Rica y Centroam [Internet]. 2011 [citado 10/03/2020]; LXVIII (599): 515-518. Disponible en: http://www.medigraphic.com/pdfs/revmedcoscen/rmc-2011/rmc114w.pdf
5. Vargas Solórzano Y. Tumor de Wilms. Rev Med Costa Rica y Centroam [Internet]. 2013 [citado 10/03/2020]; LXX (605): 55-57. Disponible en: http://www.medigraphic.com/pdfs/revmedcoscen/rmc-2013/rmc131k.pdf
6. Seminara C, Planells MC, Pogonza RE, Morales M, Castro C, Sferco A, et al. Tumor de Wilms: experiencia de 15 años en un Hospital de niños, Córdoba, Argentina. Arch Argent Pediatr [Internet]. 2019 [citado 10/03/2020]; 117(4): 263-270. Disponible en: https://pmlegacy.ncbi.nlm.nih.gov/pubmed/?term=Tumor+de+wilms%3A+experiencia+de+15+años+en+un+hospital+de+niños
7. Herrera-Toro NH, Peña-Aguirre L, Arango-Rave ME. Tumor de Wilms: experiencia de 12 años en dos hospitales de alto nivel en Medellín, Colombia. IATREIA [Internet]. 2019 [citado 19/03/2020]; 32(2): 82-91. Disponible en: http://www.scielo.org.co/scielo.php?pid=S0121-07932019000200082&script=sci_abstract&tlng=es
8. Irtan S, Ehrlich PF, Pritchard-Jones K. Wilms tumor: “State of the art” update, 2016. Semin Pediatr Surg [Internet]. 2016 [citado 19/03/2020]; 25(5): 250-6. Disponible en: https://www.sciencedirect.com/science/article/abs/pii/S1055858616300415
9. Cordero MG, Aldrink JH, O’Brien SH, Yin H, Arnold MA, Ranalli MA. Renal tumors in children younger than 12 months of age: a 65-year single institution review. J Pediatr Hematol Oncol [Internet]. 2017 [citado 19/03/2020]; 39(2): 103-7. Disponible en: https://pmlegacy.ncbi.nlm.nih.gov/pubmed/?term=Renal+tumors+in+children+younger+than+12+minths+of+age%3A+a+65-year+single+institution+review
10. Xiao‑Hui T, De‑Ying Z, Xing L, Tao L, Da‑Wei H, Xu‑Liang L, et al. Retrospective analysis to determine outcomes of patients with bilateral Wilms tumor undergoing nephron sparing surgery: 15-year tertiary single-institution experience. Pediatr Surg Int [Internet]. 2018 [citado 19/03/2020]; 34(4): 427-33. Disponible en: https://pubmed.ncbi.nlm.nih.gov/29368077
11. Guerrero E, Alvarado R, Urdiales A, Orbe MJ, Navarrete O, Manterola C. Tumor de Wilms: estudio de centro único de los andes ecuatorianos. Serie de casos con seguimiento. Int J Morphol [Internet]. 2020 [citado 05/04/2020]; 38(1): 208-214. Disponible en: https://scielo.conicyt.cl/scielo.php?pid=S0717-95022020000100208&script=sci_arttext
12. Lecca-Zavaleta JL, Salirrosas Bermudez SV. Dolor abdominal agudo secundario a la rotura de tumor de Wilms: reporte de caso. Urol Colomb [Internet]. 2019 [citado 19/03/2020]; 28(1): 88–91. Disponible en: https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0038-1651511?device=mobile&innerWidth=360&offsetWidth=360
13. Jia-Yi P, Hsing-Ju W, Su-Boon Y. Atypical presentation of Wilmstumor, an 11-year-old girl with abdominal pain and anemia: a case report. Int J Clin Exp Med [Internet]. 2019 [citado 19/03/2020]; 12(7): 9463-9467. Disponible en: https://1library.net/document/qvl5on0y-case-report-atypical-presentation-wilms-abdominal-anemia-report.html
14. Millar AJ, Cox S, Davidson A. Management of bilateral Wilms tumours. Pediatr Surg Int [Internet]. 2017 [citado 27/03/2020]; 33: 461-469. Disponible en: https://www.ncbi.nlm.nih.gov/m/pubmed/28516188
15. Mahamdallie S, Yost S, Poyastro-Pearson E, Holt E, Zachariou A, Seal S, et al. Identification of new Wilms tumour predisposition genes: an exome sequencing study. Lancet Child Adolesc Health [Internet]. 2019 [citado 27/03/2020]; 3: 322–31. Disponible en: https://www.sciencedirect.com/science/article/pii/S2352464219300185
16. Dirección Nacional de Estadísticas. Anuario Estadístico de Salud [Internet]. La Habana: MINSAP; 2020 [citado 15/05/2020]. Disponible en: http://www.sld.cu/anuncio/2020/05/09/publicado-el-anuario-estadistico-de-salud-2019
17. Graverán Sánchez LA, Verdecia Cañizares C, Alonso Pírez M, Pineda Fernández D. Nefroblastoma o tumor de Wilms teratomatoso. Rev Cubana Pediatr [Internet]. 2017 [citado 19/03/2020]; 89(4): 1-9. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0034-75312017000400011&lng=es
18. Llort Sales A, Gros Subias L. Tumores renales en la infancia y adolescencia. Pediat Integral [Internet]. 2016 [citado 19/03/2020]; 20(7): 447 -457. Disponible en: https://www.pediatriaintegral.es/publicacion-2016-09/tumores-renales-en-la-infancia-y-adolescencia/
19. Quirós-Mata M, Gamboa-Chaves AY. Tumor de Wilms en niños de Costa Rica. Acta Med Costarric [Internet]. 2018 [citado 05/04/2020]; 60(1): 15-20. Disponible en: http://www.scielo.sa.cr/scielo.php?script=sci_arttext&pid=S0001-60022018000100015
20. Fernandez C, Geller JI, Ehrlich PF, et al. Renal Tumors. In: Pizzo PA, Poplack DG, Adamson PC, et al, editors. Principles and Practice of Pediatric Oncology. 7th ed. Philadelphia: Wolters-Kluwer; 2016. p. 753-71.
21. Chung E, Graeber A Conran R. Renal Tumors of Childhood: Radiologic-Pathologic Correlation. Radiographics [Internet]. 2016 [citado 19/03/2020]; 36(2): 499-522. Disponible en: https://pubs.rsna.org/doi/full/10.1148/rg.2016150230
22. Vujanić G, Gessler M, Ooms A, Collini P, Coulomb-l’Hermine A, D’Hooghe E, et al. The UMBRELLA SIOP-RTSG 2016 Wilms tumour pathology and molecular biology protocol. Nat Rev Urol [Internet]. 2018 [citado 05/04/2020]; 15(11): 693-701. Disponible en: https://www.ncbi.nlm.nih.gov/m/pubmed/30310143
23. Caldwell BT, Wilcox DT, Cost NG. Current Management for Pediatric Urologic Oncology. Adv Pediatr [Internet]. 2017 Aug [citado 05/04/2020]; 64(1): 191-223. Disponible en: https://www.ncbi.nlm.nih.gov/m/pubmed/28688589
24. Dix DB, Seibel N, Chi YY, Khanna G, Gratias E, Anderson J, et al. Treatment of stage IV favorable histology Wilms tumor with lung metastases: a report from the children's oncology group AREN0533 Study. J Clin Oncol [Internet]. 2018 [citado 05/04/2020]; 36(16): 1564-70. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6075846/
25. Pritchard Jones K, Bergeron C, Camargo B, Heuvel-Eibrink M, Cha T, Godzinki J, et al. Omission of doxorubicin from the treatment of stage II-III intermediate-risk Wilms Tumor (SIOP WT-2001): an open label, non inferiority, randomised controlled trial. Lancet [Internet]. 2015 [citado 19/03/2020]; 386: 1156–64. Disponible en: https://pubmed.ncbi.nlm.nih.gov/26164096/
26. Stokes C, Stokes W, Kalapurakal J, Paulino A, Cost N, Cost C, et al. Timing of Radiation Therapy in Pediatric Wilms Tumor: A Report From the National Cancer Database. Int J Radiat Oncol Biol Phys [Internet]. 2018 [citado 19/03/2020]; 101(2): 453-61. Disponible en: https://www.ncbi.nlm.nih.gov/m/pubmed/29559286
2. Mirabal Fariñas A, Yalcouye H, Pantoja Blanco M, Cobas Landeau C, Romero García LI. Características clinicoterapéuticas de niños y adolescentes con neoplasias renales. MEDISAN [Internet]. 2015 [citado 10/03/2020]; 19(7): 821-30. Disponible en: http://www.medisan.sld.cu/index.php/san/article/view/378/html_101
3. Quero-Hernández A, Hernández Arriola J, Reyes Gómez U, Álvarez Solís RM, Vargas M, Tenorio Rodríguez H. Tumor de Wilms. Características clínicas y resultados del tratamiento. Pediat Mex [Internet]. 2011 [citado 10/03/2020]; 13(3): 109-113. Disponible en: http://www.medigraphic.com/pdfs/conapeme/pm-2011/pm113e.pdf
4. Rojas Barrantes EI. Tumor de Willms. Rev Med Costa Rica y Centroam [Internet]. 2011 [citado 10/03/2020]; LXVIII (599): 515-518. Disponible en: http://www.medigraphic.com/pdfs/revmedcoscen/rmc-2011/rmc114w.pdf
5. Vargas Solórzano Y. Tumor de Wilms. Rev Med Costa Rica y Centroam [Internet]. 2013 [citado 10/03/2020]; LXX (605): 55-57. Disponible en: http://www.medigraphic.com/pdfs/revmedcoscen/rmc-2013/rmc131k.pdf
6. Seminara C, Planells MC, Pogonza RE, Morales M, Castro C, Sferco A, et al. Tumor de Wilms: experiencia de 15 años en un Hospital de niños, Córdoba, Argentina. Arch Argent Pediatr [Internet]. 2019 [citado 10/03/2020]; 117(4): 263-270. Disponible en: https://pmlegacy.ncbi.nlm.nih.gov/pubmed/?term=Tumor+de+wilms%3A+experiencia+de+15+años+en+un+hospital+de+niños
7. Herrera-Toro NH, Peña-Aguirre L, Arango-Rave ME. Tumor de Wilms: experiencia de 12 años en dos hospitales de alto nivel en Medellín, Colombia. IATREIA [Internet]. 2019 [citado 19/03/2020]; 32(2): 82-91. Disponible en: http://www.scielo.org.co/scielo.php?pid=S0121-07932019000200082&script=sci_abstract&tlng=es
8. Irtan S, Ehrlich PF, Pritchard-Jones K. Wilms tumor: “State of the art” update, 2016. Semin Pediatr Surg [Internet]. 2016 [citado 19/03/2020]; 25(5): 250-6. Disponible en: https://www.sciencedirect.com/science/article/abs/pii/S1055858616300415
9. Cordero MG, Aldrink JH, O’Brien SH, Yin H, Arnold MA, Ranalli MA. Renal tumors in children younger than 12 months of age: a 65-year single institution review. J Pediatr Hematol Oncol [Internet]. 2017 [citado 19/03/2020]; 39(2): 103-7. Disponible en: https://pmlegacy.ncbi.nlm.nih.gov/pubmed/?term=Renal+tumors+in+children+younger+than+12+minths+of+age%3A+a+65-year+single+institution+review
10. Xiao‑Hui T, De‑Ying Z, Xing L, Tao L, Da‑Wei H, Xu‑Liang L, et al. Retrospective analysis to determine outcomes of patients with bilateral Wilms tumor undergoing nephron sparing surgery: 15-year tertiary single-institution experience. Pediatr Surg Int [Internet]. 2018 [citado 19/03/2020]; 34(4): 427-33. Disponible en: https://pubmed.ncbi.nlm.nih.gov/29368077
11. Guerrero E, Alvarado R, Urdiales A, Orbe MJ, Navarrete O, Manterola C. Tumor de Wilms: estudio de centro único de los andes ecuatorianos. Serie de casos con seguimiento. Int J Morphol [Internet]. 2020 [citado 05/04/2020]; 38(1): 208-214. Disponible en: https://scielo.conicyt.cl/scielo.php?pid=S0717-95022020000100208&script=sci_arttext
12. Lecca-Zavaleta JL, Salirrosas Bermudez SV. Dolor abdominal agudo secundario a la rotura de tumor de Wilms: reporte de caso. Urol Colomb [Internet]. 2019 [citado 19/03/2020]; 28(1): 88–91. Disponible en: https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0038-1651511?device=mobile&innerWidth=360&offsetWidth=360
13. Jia-Yi P, Hsing-Ju W, Su-Boon Y. Atypical presentation of Wilmstumor, an 11-year-old girl with abdominal pain and anemia: a case report. Int J Clin Exp Med [Internet]. 2019 [citado 19/03/2020]; 12(7): 9463-9467. Disponible en: https://1library.net/document/qvl5on0y-case-report-atypical-presentation-wilms-abdominal-anemia-report.html
14. Millar AJ, Cox S, Davidson A. Management of bilateral Wilms tumours. Pediatr Surg Int [Internet]. 2017 [citado 27/03/2020]; 33: 461-469. Disponible en: https://www.ncbi.nlm.nih.gov/m/pubmed/28516188
15. Mahamdallie S, Yost S, Poyastro-Pearson E, Holt E, Zachariou A, Seal S, et al. Identification of new Wilms tumour predisposition genes: an exome sequencing study. Lancet Child Adolesc Health [Internet]. 2019 [citado 27/03/2020]; 3: 322–31. Disponible en: https://www.sciencedirect.com/science/article/pii/S2352464219300185
16. Dirección Nacional de Estadísticas. Anuario Estadístico de Salud [Internet]. La Habana: MINSAP; 2020 [citado 15/05/2020]. Disponible en: http://www.sld.cu/anuncio/2020/05/09/publicado-el-anuario-estadistico-de-salud-2019
17. Graverán Sánchez LA, Verdecia Cañizares C, Alonso Pírez M, Pineda Fernández D. Nefroblastoma o tumor de Wilms teratomatoso. Rev Cubana Pediatr [Internet]. 2017 [citado 19/03/2020]; 89(4): 1-9. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0034-75312017000400011&lng=es
18. Llort Sales A, Gros Subias L. Tumores renales en la infancia y adolescencia. Pediat Integral [Internet]. 2016 [citado 19/03/2020]; 20(7): 447 -457. Disponible en: https://www.pediatriaintegral.es/publicacion-2016-09/tumores-renales-en-la-infancia-y-adolescencia/
19. Quirós-Mata M, Gamboa-Chaves AY. Tumor de Wilms en niños de Costa Rica. Acta Med Costarric [Internet]. 2018 [citado 05/04/2020]; 60(1): 15-20. Disponible en: http://www.scielo.sa.cr/scielo.php?script=sci_arttext&pid=S0001-60022018000100015
20. Fernandez C, Geller JI, Ehrlich PF, et al. Renal Tumors. In: Pizzo PA, Poplack DG, Adamson PC, et al, editors. Principles and Practice of Pediatric Oncology. 7th ed. Philadelphia: Wolters-Kluwer; 2016. p. 753-71.
21. Chung E, Graeber A Conran R. Renal Tumors of Childhood: Radiologic-Pathologic Correlation. Radiographics [Internet]. 2016 [citado 19/03/2020]; 36(2): 499-522. Disponible en: https://pubs.rsna.org/doi/full/10.1148/rg.2016150230
22. Vujanić G, Gessler M, Ooms A, Collini P, Coulomb-l’Hermine A, D’Hooghe E, et al. The UMBRELLA SIOP-RTSG 2016 Wilms tumour pathology and molecular biology protocol. Nat Rev Urol [Internet]. 2018 [citado 05/04/2020]; 15(11): 693-701. Disponible en: https://www.ncbi.nlm.nih.gov/m/pubmed/30310143
23. Caldwell BT, Wilcox DT, Cost NG. Current Management for Pediatric Urologic Oncology. Adv Pediatr [Internet]. 2017 Aug [citado 05/04/2020]; 64(1): 191-223. Disponible en: https://www.ncbi.nlm.nih.gov/m/pubmed/28688589
24. Dix DB, Seibel N, Chi YY, Khanna G, Gratias E, Anderson J, et al. Treatment of stage IV favorable histology Wilms tumor with lung metastases: a report from the children's oncology group AREN0533 Study. J Clin Oncol [Internet]. 2018 [citado 05/04/2020]; 36(16): 1564-70. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6075846/
25. Pritchard Jones K, Bergeron C, Camargo B, Heuvel-Eibrink M, Cha T, Godzinki J, et al. Omission of doxorubicin from the treatment of stage II-III intermediate-risk Wilms Tumor (SIOP WT-2001): an open label, non inferiority, randomised controlled trial. Lancet [Internet]. 2015 [citado 19/03/2020]; 386: 1156–64. Disponible en: https://pubmed.ncbi.nlm.nih.gov/26164096/
26. Stokes C, Stokes W, Kalapurakal J, Paulino A, Cost N, Cost C, et al. Timing of Radiation Therapy in Pediatric Wilms Tumor: A Report From the National Cancer Database. Int J Radiat Oncol Biol Phys [Internet]. 2018 [citado 19/03/2020]; 101(2): 453-61. Disponible en: https://www.ncbi.nlm.nih.gov/m/pubmed/29559286
Downloads
Published
2020-07-16
How to Cite
1.
Mollinedo-Rangel O, Acuña-Amador AT, Roque-Pérez L. Considerations on the treatment of Wilms’ tumor. Univ. Méd. Pinareña [Internet]. 2020 Jul. 16 [cited 2025 Apr. 16];18(1):e560. Available from: https://revgaleno.sld.cu/index.php/ump/article/view/560
Issue
Section
Review article
